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On April 16, 1943, Swiss chemist Albert Hofmann was doing just another experiment on a lysergic acid compound, when he accidentally absorbed some through his fingertips. Three days later, he ingested 250 micrograms of the compound and hopped on his bike to make his way home. That’s when he started to experience the world’s first acid trip:

“In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away.”

He continued to experiment with hallucinogens, becoming the first person to synthesize psilocybin, the active ingredient in magic mushrooms, in 1958. While he was critical of casual hippie LSD use, he was still a lifelong advocate of the drug he referred to as “medicine for the soul.” Hofman finally died yesterday of a heart attack at the ripe old age of 102. After the jump, watch a documentary about the development of LSD called Hofmann’s Potion.